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Article

The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure.

International journal of biological macromolecules - 1 Oct 2018

Zhu Sha, Xi Xi-Bo, Duan Tian-Li, Zhai Yi, Li Jinyu, Yan Yong-Bin, Yao Ke

Abstract excerpt

Congenital cataract is one of the leading causes of childhood blindness worldwide. About half of heredity cataracts are caused by mutations in various crystallins. However, the underlying mechanisms have not been elucidated for most of crystallin mutations. In this research, we studied the effect of a cataract-causing mutation G75V on γS-crystallin structure, stability and aggregatory propensity. Spectroscopic...

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Source

Identifiers

PMID: 29857103
DOI: 10.1016/j.ijbiomac.2018.05.220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure.PMID 29857103Read ↗

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