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Article

A novel cataract-causing mutation Ile82Met of γA crystallin trends to aggregate with unfolding intermediate.

International journal of biological macromolecules - 30 Jun 2022

Xu Wanyue, Xu Jingjie, Shi Caiping, Wu Jing, Wang Huaxia, Wu Wei, Chen Xiangjun, Hu Lidan

Abstract excerpt

Cataract is the most common pathogenic ophthalmic disease leading to blindness in children worldwide. Genetic disorder is the leading cause of congenital cataract, among which crystallin mutations have a high incidence. There are few reports on γA-crystallin, one critical member of crystallin superfamilies. In this study, we identified a novel pathogenic mutation (Ile82Met) in γA-crystallin from a...

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Identifiers

PMID: 35513103
DOI: 10.1016/j.ijbiomac.2022.04.205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel cataract-causing mutation Ile82Met of γA crystallin trends to aggregate with unfolding intermediate.PMID 35513103Read ↗

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Human γS-Crystallin Mutation F10_Y11delinsLN in the First Greek Key Pair Destabilizes and Impairs Tight Packing Causing Cortical Lamellar Cataract.Semantic proximity Read ↗

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