Article

Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging

2021-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Cataract disease, a clouding of the eye lens due to precipitation of lens proteins, affects millions of people every year worldwide. The proteins that comprise the lens, the crystallins, show extensive post-translational modifications (PTMs) in aged and cataractous lenses, most commonly deamidation and oxidation. Although surface-exposed glutamines and asparagines show the highest rates of deami...

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Literature Corpus work: 706ab64a-a4ee-5c09-b1e0-5cdcebbd20ed
DOI: 10.1101/2021.06.21.449298

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