Article
Identification of the Most Impactful Asparagine Residues for γS-Crystallin Aggregation by Deamidation.
Biochemistry - 6 Jun 2023
Kato Koichi, Nakayoshi Tomoki, Kitamura Yuki, Kurimoto Eiji, Oda Akifumi, Ishikawa Yoshinobu
Abstract excerpt
Crystallin aggregation in the eye lens is involved in the pathogenesis of cataracts. The aggregation is considered to be promoted by non-enzymatic post-translational modifications, such as the deamidation and stereoinversion of amino acid residues. Although in a previous study, the deamidated asparagine residues were detected in γS-crystallin in vivo, it is unclear which deamidated residues have the most impact...
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