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Article

Deamidation in human lens betaB2-crystallin destabilizes the dimer.

Biochemistry - 14 Mar 2006

Lampi Kirsten J, Amyx Kencee K, Ahmann Petra, Steel Eric A

Abstract excerpt

Two major determinants of the transparency of the lens are protein-protein interactions and stability of the crystallins, the structural proteins in the lens. betaB2 is the most abundant beta-crystallin in the human lens and is important in formation of the complex interactions of lens crystallins. betaB2 readily forms a homodimer in vitro, with interacting residues across the monomer-monomer interface conserved...

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Identifiers

PMID: 16519509
DOI: 10.1021/bi052051k
PMCID: PMC2533042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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