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Article

Conformational stability of the deamidated and mutated human βB2-crystallin.

Biophysical chemistry - 1 May 2023

Velasco-Bolom José-Luis, Dominguez Laura

Abstract excerpt

Previous studies propose that genetic mutations and post-translational modifications in protein crystallins promote protein aggregation and are considered significant risk factors for cataract formation. The βB2-crystallin (HβB2C) forms a high proportion of proteins in the human eye lens. Different congenital mutations and post-translational deamidations in βB2-crystallin have been reported and linked to cataract...

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Cataract
Lens, Crystalline
Molecular Conformation
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36905841
DOI: 10.1016/j.bpc.2023.106986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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