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Article

Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin.

The Journal of biological chemistry - 27 Nov 2009

Moreau Kate L, King Jonathan

Abstract excerpt

The human eye lens is composed of fiber cells packed with crystallins up to 450 mg/ml. Human gammaD-crystallin (HgammaD-Crys) is a monomeric, two-domain protein of the lens central nucleus. Both domains of this long lived protein have double Greek key beta-sheet folds with well packed hydrophobic cores. Three mutations resulting in amino acid substitutions in the gamma-crystallin buried cores (two in the...

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Identifiers

PMID: 19758984
DOI: 10.1074/jbc.M109.031344
PMCID: PMC2785171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin.PMID 19758984Read ↗

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