Role of the aldehyde dehydrogenase-1 isozyme in the metabolism of acetaldehyde.

doi:10.1093/alcalc/28.supplement_1b.15

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Article

Role of the aldehyde dehydrogenase-1 isozyme in the metabolism of acetaldehyde.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1993

Ueshima Y, Matsuda Y, Tsutsumi M, Takada A

Abstract excerpt

At least four types of aldehyde dehydrogenase (ALDH) isozymes exist in human liver: acetaldehyde (Ac-CHO) is metabolized mainly by ALDH2. However, the role of ALDH1 in Ac-CHO metabolism is not well known, because ALDH1 deficiency is rare. In the present study, changes in blood levels of Ac-CHO were analyzed in a person with ALDH1 deficiency who is also heterozygous for the ALDH2 alleles, and subjects with normal...

Topics

Acetaldehyde
Adult
Alcohol Drinking
Aldehyde Oxidoreductases
Alleles
Cells, Cultured
Erythrocytes
Ethanol
Female
Genotype
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Isoelectric Focusing

Isoenzymes

Liver

Male

Pedigree

Source

Open in PubMed

Identifiers

PMID: 8003124
DOI: 10.1093/alcalc/28.supplement_1b.15

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8003124-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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