Article
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.
Blood - 11 Jun 2009
Grand Francis H, Hidalgo-Curtis Claire E, Ernst Thomas, Zoi Katerina, Zoi Christine, McGuire Carolann, Kreil Sebastian, Jones Amy, Score Joannah, Metzgeroth Georgia, Oscier David, Hall Andrew, Brandts Christian, Serve Hubert, Reiter Andreas, Chase Andrew J, Cross Nicholas C P
Abstract excerpt
Recent evidence has demonstrated that acquired uniparental disomy (aUPD) is a novel mechanism by which pathogenetic mutations in cancer may be reduced to homozygosity. To help identify novel mutations in myeloproliferative neoplasms (MPNs), we performed a genome-wide single nucleotide polymorphism (SNP) screen to identify aUPD in 58 patients with atypical chronic myeloid leukemia (aCML; n = 30), JAK2...
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