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Article

IL-4 rescues surface IgM expression in chronic lymphocytic leukemia

26 May 2016

Abstract excerpt

Chronic lymphocytic leukemia (CLL) cells express poor levels of surface immunoglobulin (sIg), and many are minimally activated or anergic in response to B-cell receptor (BCR) crosslinking in vitro. Paradoxically, CLL cells in patients are highly activated through BCR signaling and expand in proliferation centers, suggesting that the function of sIg signaling is rescued. Here, we find that, compared with normal...

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PMID: 27226435
DOI: 10.1182/blood-2015-11-682997

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