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Article

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

Blood - 11 Aug 2016

D'Avola Annalisa, Drennan Samantha, Tracy Ian, Henderson Isla, Chiecchio Laura, Larrayoz Marta, Rose-Zerilli Matthew, Strefford Jonathan, Plass Christoph, Johnson Peter W, Steele Andrew J, Packham Graham, Stevenson Freda K, Oakes Christopher C, Forconi Francesco

Abstract excerpt

Chronic lymphocytic leukemia (CLL) with unmutated (U-CLL) or mutated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) displays different states of anergy, indicated by reduced surface immunoglobulin M (sIgM) levels and signaling, consequent to chronic (super)antigen exposure. The subsets also differ in the incidence of high-risk genetic aberrations and in DNA methylation profile, preserved from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27301861
DOI: 10.1182/blood-2016-03-707786

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NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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