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Article

Follicular lymphoma evolves with a surmountable dependency on acquired glycosylation motifs in the B-cell receptor

8 Sept 2023

Abstract excerpt

ABSTRACT: An early event in the genesis of follicular lymphoma (FL) is the acquisition of new glycosylation motifs in the B-cell receptor (BCR) due to gene rearrangement and/or somatic hypermutation. These N-linked glycosylation motifs (N-motifs) contain mannose-terminated glycans and can interact with lectins in the tumor microenvironment, activating the tumor BCR pathway. N-motifs are stable during FL...

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Share to Glycosylation and Glycoproteins Research
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PMID: 37683139
DOI: 10.1182/blood.2023020360

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