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Article

Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis.

Arthritis care & research - 1 Jul 2013

Karlson Elizabeth W, Ding Bo, Keenan Brendan T, Liao Katherine, Costenbader Karen H, Klareskog Lars, Alfredsson Lars, Chibnik Lori B

Abstract excerpt

OBJECTIVE: We developed rheumatoid arthritis (RA) risk models based on validated environmental factors (E), genetic risk scores (GRS), and gene-environment interactions (GEI) to identify factors that can improve accuracy and reclassification. METHODS: Models including E, GRS, and GEI were developed among 317 white seropositive RA cases and 551 controls from the Nurses' Health Studies (NHS) and validated in 987...

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Identifiers

PMID: 23495093
DOI: 10.1002/acr.22005
PMCID: PMC3740546

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NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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