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A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis

16 Mar 2010

Abstract excerpt

Mutations of the immunoglobulin superfamily proteins nephrin and Neph1 lead to congenital nephrotic syndrome in humans or mice. Neph proteins are three closely related molecules that are evolutionarily conserved and mediate cell recognition. Their importance for morphogenetic processes including the formation of the kidney filtration barrier in vertebrates and synaptogenesis in Caenorhabditis elegans has recently...

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PMID: 20233749
DOI: 10.1093/hmg/ddq108

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