Article
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis.
PloS one - 1 Jan 2011
Wanner Nicola, Noutsou Foteini, Baumeister Ralf, Walz Gerd, Huber Tobias B, Neumann-Haefelin Elke
Abstract excerpt
The assembly of specific synaptic connections represents a prime example of cellular recognition. Members of the Ig superfamily are among the most ancient proteins represented in the genomes of both mammalian and invertebrate organisms, where they constitute a trans-synaptic adhesion system. The correct connectivity patterns of the highly conserved immunoglobulin superfamily proteins nephrin and Neph1 are crucial...
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