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Article

Functional study of mammalian Neph proteins in Drosophila melanogaster.

PloS one - 1 Jan 2012

Helmstädter Martin, Lüthy Kevin, Gödel Markus, Simons Matias, Ashish, Nihalani Deepak, Rensing Stefan A, Fischbach Karl-Friedrich, Huber Tobias B

Abstract excerpt

Neph molecules are highly conserved immunoglobulin superfamily proteins (IgSF) which are essential for multiple morphogenetic processes, including glomerular development in mammals and neuronal as well as nephrocyte development in D. melanogaster. While D. melanogaster expresses two Neph-like proteins (Kirre and IrreC/Rst), three Neph proteins (Neph1-3) are expressed in the mammalian system. However, although...

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PMID: 22792268
DOI: 10.1371/journal.pone.0040300
PMCID: PMC3391254

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