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Article

Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros.

Molecular medicine reports - 1 Feb 2014

Fukuyo Yayoi, Nakamura Tomomi, Bubenshchikova Ekaterina, Powell Rebecca, Tsuji Takashi, Janknecht Ralf, Obara Tomoko

Abstract excerpt

The slit diaphragm (SD) is a highly specialized intercellular junction between podocyte foot processes and is crucial in the formation of the filtration barrier in the renal glomeruli. Zebrafish Nephrin and Podocin are important in the formation of the podocyte SD and mutations in NEPHRIN and PODOCIN genes cause human nephrotic syndrome. In the present study, the zebrafish Podocin protein was observed to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24337247
DOI: 10.3892/mmr.2013.1844
PMCID: PMC3896505

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