Article
Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma.
Biochemical and biophysical research communications - 9 Apr 2010
Schilling Tobias, Kairat Astrid, Melino Gerry, Krammer Peter H, Stremmel Wolfgang, Oren Moshe, Müller Martina
Abstract excerpt
Whereas the hallmark of wild-type p53 is its tumor suppressor activity, tumor-associated mutant p53 proteins can exert novel anti-apoptotic gain-of-function activities, which confer a selective advantage upon tumor cells harboring such mutations. We investigated the molecular mechanisms of mutant p53 gain-of-function in hepatocellular carcinoma with special emphasis on the interaction of mutant p53...
Topics
- Apoptosis
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Humans
- Liver Neoplasms
- Metabolic Networks and Pathways
- Mutation
- Nuclear Proteins