Article
Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK.
Science signaling - 3 Apr 2018
Wolf Eric R, McAtarsney Ciarán P, Bredhold Kristin E, Kline Amber M, Mayo Lindsey D
Abstract excerpt
The transcription factors p53 and p73 are critical to the induction of apoptotic cell death, particularly in response to cell stress that activates c-Jun N-terminal kinase (JNK). Mutations in the DNA-binding domain of p53, which are commonly seen in cancers, result in conformational changes that enable p53 to interact with and inhibit p73, thereby suppressing apoptosis. In contrast, wild-type p53 reportedly does...
Topics
- Apoptosis
- Apoptosis Regulatory Proteins
- Binding Sites
- Cell Line, Tumor
- Cell Survival
- Humans
- JNK Mitogen-Activated Protein Kinases
- Models, Molecular
- Mutation
- Phosphorylation
- Protein Binding