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Article

It takes a team: a gain-of-function story of p53-R249S

3 Jan 2019

Abstract excerpt

Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and R273 with distinct molecular mechanisms. Yet, less is known about another hotspot p53 mutant, R249S (p53-R249S). p53-R249S is the sole hotspot mutation in hepatocellular carcinoma (HCC) that is highly associated with chronic hepatitis B virus (HBV)...

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PMID: 30608603
DOI: 10.1093/jmcb/mjy086

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