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Article

Regulation of cytotoxic T-cell responses by p53 in cancer

1 Dec 2016

Abstract excerpt

An intriguing aspect of the tumor suppressor p53 is its ability to communicate to the adaptive immune system and control the cytotoxic T-lymphocyte (CTL) response to cancer cells. Wild-type p53 (wtp53) communicates with CTLs through proteins involved in the major histocompatibility complex (MHC) class I antigen presentation pathway [e.g., transporter associated with antigen processing 1 (TAP1) and endoplasmic...

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Identifiers

PMID: 28944167
DOI: 10.21037/tcr.2016.11.76

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