Article
P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.
Oncogene - 17 Jul 2008
Sayan A E, Sayan B S, Gogvadze V, Dinsdale D, Nyman U, Hansen T M, Zhivotovsky B, Cohen G M, Knight R A, Melino G
Abstract excerpt
The p73 protein, a member of the p53 family, has both developmental and tumorigenic functions. Here we show that p73 is cleaved by caspase-3 and -8 both in vitro and in vivo during apoptosis elicited by DNA-damaging drugs and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor ligation. TAp73 and some of its cleavage products are localized to mitochondria. siRNA-mediated downregulation of p73...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.