Article
Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants.
Oncogene - 28 Aug 2003
Zalcenstein Amir, Stambolsky Perry, Weisz Lilach, Müller Martina, Wallach David, Goncharov Tanya M, Krammer Peter H, Rotter Varda, Oren Moshe
Abstract excerpt
Tumor-associated mutant forms of p53 can exert an antiapoptotic gain of function activity, which probably confers a selective advantage upon tumor cells harboring such mutations. We report that mutant p53 suppresses the expression of the CD95 (Fas/APO-1) gene, encoding a death receptor implicated in a variety of apoptotic responses. Moderate (40-50%) downregulation of CD95 mRNA and surface protein expression by...
Topics
- Apoptosis
- Down-Regulation
- Humans
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- Repressor Proteins
- Tumor Suppressor Protein p53
- fas Receptor