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Article

Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2010

Guo Huan, Bai Yun, Xu Ping, Hu Zhibin, Liu Li, Wang Fang, Jin Guangfu, Wang Feng, Deng Qifei, Tu Yixiao, Feng Maohui, Lu Daru, Shen Hongbing, Wu Tangchun

Abstract excerpt

PURPOSE Heat-shock protein 27 (Hsp27), encoded by HSPB1, plays crucial roles in tumorigenesis and cell survival and is reported to be an independent prognosis marker for cancer. We hypothesized that genetic variants of the HSPB1 gene may be associated with lung cancer susceptibility and survival. PATIENTS AND METHODS We first resequenced the full-length HSPB1 gene and then genotyped three selected tag single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20231684
DOI: 10.1200/JCO.2009.24.4954

Genes

HSPB1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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