Association of single nucleotide polymorphisms rs7459185 of the HSPβ1 gene and the risk of hematological toxicity in lung cancer.

doi:10.1016/j.lungcan.2025.108103

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Article

Association of single nucleotide polymorphisms rs7459185 of the HSPβ1 gene and the risk of hematological toxicity in lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2025

Muñoz Óscar Muñoz, Delgado León Blas David, Sellés Elías Gomis, Enguix-Riego María Valle, Fernández de Bobadilla Jon Cacicedo, Praena-Fernández Juan Manuel, Del Campo Eleonor Rivin, López Guerra José Luis

Abstract excerpt

PURPOSE: Hematological toxicities (HTs) in lung cancer (LCa) may compromise the delivery of Radio-Chemotherapy (RTCT), and consequently affect the control of the disease. The aim of this study is to evaluate the association of Single nucleotide polymorphisms (SNPs) with HT. MATERIAL/METHODS: In this prospective multicentre study, 264 patients with primary LCa treated with RTCT between 2012 and 2018 were included....

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Adult
Aged
Aged, 80 and over
Female
Humans
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Chemoradiotherapy

Genetic Predisposition to Disease

Genotype

Hematologic Diseases

Lung Neoplasms

Polymorphism, Single Nucleotide

Prospective Studies

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Identifiers

PMID: 39862642
DOI: 10.1016/j.lungcan.2025.108103

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