Article
Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.
Blood - 10 Sept 2015
Huffman Jennifer E, de Vries Paul S, Morrison Alanna C, Sabater-Lleal Maria, Kacprowski Tim, Auer Paul L, Brody Jennifer A, Chasman Daniel I, Chen Ming-Huei, Guo Xiuqing, Lin Li-An, Marioni Riccardo E, Müller-Nurasyid Martina, Yanek Lisa R, Pankratz Nathan, Grove Megan L, de Maat Moniek P M, Cushman Mary, Wiggins Kerri L, Qi Lihong, Sennblad Bengt, Harris Sarah E, Polasek Ozren, Riess Helene, Rivadeneira Fernando, Rose Lynda M, Goel Anuj, Taylor Kent D, Teumer Alexander, Uitterlinden André G, Vaidya Dhananjay, Yao Jie, Tang Weihong, Levy Daniel, Waldenberger Melanie, Becker Diane M, Folsom Aaron R, Giulianini Franco, Greinacher Andreas, Hofman Albert, Huang Chiang-Ching, Kooperberg Charles, Silveira Angela, Starr John M, Strauch Konstantin, Strawbridge Rona J, Wright Alan F, McKnight Barbara, Franco Oscar H, Zakai Neil, Mathias Rasika A, Psaty Bruce M, Ridker Paul M, Tofler Geoffrey H, Völker Uwe, Watkins Hugh, Fornage Myriam, Hamsten Anders, Deary Ian J, Boerwinkle Eric, Koenig Wolfgang, Rotter Jerome I, Hayward Caroline, Dehghan Abbas, Reiner Alex P, O'Donnell Christopher J, Smith Nicholas L
Abstract excerpt
Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency...
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