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Article

Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Paradis P, Dali-Youcef N, Paradis F W, Thibault G, Nemer M

Abstract excerpt

Angiotensin II (AII) is a major determinant of arterial pressure and volume homeostasis, mainly because of its vascular action via the AII type 1 receptor (AT1R). AII has also been implicated in the development of cardiac hypertrophy because angiotensin I-converting enzyme inhibitors and AT1R antagonists prevent or regress ventricular hypertrophy in animal models and in human. However, because these treatments...

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Identifiers

PMID: 10639182
DOI: 10.1073/pnas.97.2.931
PMCID: PMC15433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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