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Article

Signaling to cardiac hypertrophy: insights from human and mouse RASopathies.

Molecular medicine (Cambridge, Mass.) - 7 Sept 2012

Sala Valentina, Gallo Simona, Leo Christian, Gatti Stefano, Gelb Bruce D, Crepaldi Tiziana

Abstract excerpt

Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli, some of which might finally lead up to a maladaptive state. An integral part of the pathogenesis of the hypertrophic cardiomyopathy disease (HCM) is the activation of the rat sarcoma (RAS)/RAF/MEK (mitogen-activated protein kinase kinase)/MAPK (mitogen-activated protein kinase) cascade. Therefore, the molecular signaling...

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Identifiers

PMID: 22576369
DOI: 10.2119/molmed.2011.00512
PMCID: PMC3459479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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