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Article

Specific binding of a basic peptide from HIV-1 Rev.

The EMBO journal - 1 Mar 1992

Kjems J, Calnan B J, Frankel A D, Sharp P A

Abstract excerpt

Human immunodeficiency virus type I (HIV-1) encodes a regulatory protein, Rev, which is required for cytoplasmic expression of incompletely spliced viral mRNA. Rev activity is mediated through specific binding to a cis-acting Rev responsive element (RRE) located within the env region of HIV-1. A...

Topics

Amino Acid Sequence
Base Sequence
Electrophoresis, Polyacrylamide Gel
Gene Products, rev
HIV-1
Molecular Sequence Data
Mutation
Peptides
RNA Splicing
RNA, Messenger
RNA, Viral
Substrate Specificity
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rev Gene Products, Human Immunodeficiency Virus

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Open in PubMed Open full text

Identifiers

PMID: 1547776
DOI: 10.1002/j.1460-2075.1992.tb05152.x
PMCID: PMC556554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1547776-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Specific binding of a basic peptide from HIV-1 Rev.PMID 1547776Read ↗

Mutational analysis of the HIV-1 Rev protein and its target sequence, the Rev responsive element.Semantic proximity Read ↗

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HIV-1 rev nuclear export signal binding peptides isolated by phage display.Semantic proximity Read ↗

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structureSemantic proximity Read ↗

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read ↗

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Semantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Mutational analysis of functional domains in the HIV-1 Rev trans-regulatory protein.Semantic proximity Read ↗

A specific sequence with a bulged guanosine residue(s) in a stem-bulge-stem structure of Rev-responsive element RNA is required for trans activation by human immunodeficiency virus type 1 Rev.Semantic proximity Read ↗

Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminusSemantic proximity Read ↗

Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization.Semantic proximity Read ↗

Deletions near the N-terminus of HIV-1 Rev reduce RNA binding affinity and dominantly interfere with Rev function irrespective of the RNA target.Semantic proximity Read ↗

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