Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype.

doi:10.1016/0042-6822(90)90414-m

Article

Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype.

Virology - 1 Sept 1990

Venkatesh L K, Chinnadurai G

Abstract excerpt

The rev protein (Rev) of human immunodeficiency virus increases the cytoplasmic expression of viral structural gene mRNAs. We had previously reported the existence of a region (residues 73-98) near the carboxy-terminus in HIV-1 Rev essential for its function. To further define the structural elem...

Topics

Amino Acid Sequence
Animals
Cells, Cultured
Gene Expression Regulation, Viral
Gene Products, rev
HIV-1
Molecular Sequence Data
Mutation
Phenotype
RNA, Messenger
Trans-Activators
rev Gene Products, Human Immunodeficiency Virus

Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype.

Abstract excerpt

Topics

Discuss the evidence