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Article

Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming.

Regenerative medicine - 1 May 2010

Vaziri H, Chapman K B, Guigova A, Teichroeb J, Lacher M D, Sternberg H, Singec I, Briggs L, Wheeler J, Sampathkumar J, Gonzalez R, Larocca D, Murai J, Snyder E, Andrews W H, Funk W D, West M D

Abstract excerpt

AIM: To determine whether transcriptional reprogramming is capable of reversing the developmental aging of normal human somatic cells to an embryonic state. MATERIALS & METHODS: An isogenic system was utilized to facilitate an accurate assessment of the reprogramming of telomere restriction fragment (TRF) length of aged differentiated cells to that of the human embryonic stem (hES) cell line from which they were...

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Identifiers

PMID: 20230312
DOI: 10.2217/rme.10.21

Genes

KLF4
SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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