Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells

Abstract excerpt

High telomerase activity is a characteristic of human embryonic stem cells (hESCs), however, the regulation and maintenance of correct telomere length in hESCs is unclear. In this study we investigated telomere elongation in hESCs in vitro and found that telomeres lengthened from their derivation in blastocysts through early expansion, but stabilized at later passages. We report that the core unit of telomerase,...

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• Share to Chromosomal and Genetic Variations
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