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Article

The aging signature: a hallmark of induced pluripotent stem cells?

7 Nov 2013

Abstract excerpt

The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency,...

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PMID: 24256351
DOI: 10.1111/acel.12182

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