Article
Telomere dynamics in human cells reprogrammed to pluripotency.
PloS one - 2 Dec 2009
Suhr Steven T, Chang Eun Ah, Rodriguez Ramon M, Wang Kai, Ross Pablo J, Beyhan Zeki, Murthy Shashanka, Cibelli Jose B
Abstract excerpt
BACKGROUND: Human induced pluripotent stem cells (IPSCs) have enormous potential in the development of cellular models of human disease and represent a potential source of autologous cells and tissues for therapeutic use. A question remains as to the biological age of IPSCs, in particular when isolated from older subjects. Studies of cloned animals indicate that somatic cells reprogrammed to pluripotency variably...
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