Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that MEK1 positively promotes interhomologue double-strand break repair.

Nucleic acids research - 1 Jul 2010

Terentyev Yaroslav, Johnson Rebecca, Neale Matthew J, Khisroon Muhammad, Bishop-Bailey Anna, Goldman Alastair S H

Abstract excerpt

During meiosis there is an imperative to create sufficient crossovers for homologue segregation. This can be achieved during repair of programmed DNA double-strand breaks (DSBs), which are biased towards using a homologue rather than sister chromatid as a repair template. Various proteins contribute to this bias, one of which is a meiosis specific kinase Mek1. It has been proposed that Mek1 establishes the bias...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Conversion

Share to MAP Kinase Kinase 1

Share to Meiosis

Share to Proton-Translocating ATPases

Share to Recombination, Genetic

Share to Spores, Fungal

Source

Open in PubMed Open full text

Identifiers

PMID: 20223769
DOI: 10.1093/nar/gkq137
PMCID: PMC2910038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that MEK1 positively promotes interhomologue double-strand break repair.PMID 20223769Read ↗

Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response.Semantic proximity Read ↗

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complexSemantic proximity Read ↗

Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.Semantic proximity Read ↗

A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.Semantic proximity Read ↗

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Semantic proximity Read ↗

Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.Semantic proximity Read ↗

Meiotic cells monitor the status of the interhomolog recombination complex.Semantic proximity Read ↗

The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.Semantic proximity Read ↗

Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.Semantic proximity Read ↗

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Semantic proximity Read ↗

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).Semantic proximity Read ↗

Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.