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Article

A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury

28 Jan 2010

Abstract excerpt

UNLABELLED: Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment. There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify genes changing in expression in response to flucloxacillin. Changes in gene expression in human hepatocytes...

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PMID: 20222094
DOI: 10.1002/hep.23549

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