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Article

Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Oct 2008

Owen B M, Van Mil S W C, Boudjelal M, McLay I, Cairns W, Elias E, White R, Williamson C, Dixon P H

Abstract excerpt

1. The purpose of this study was to evaluate the role of coding variation in hPXR (NR1I2) in intrahepatic cholestasis of pregnancy (ICP) and to functionally asses the response of PXR variants to ligands of interest in ICP. 2. The coding region of hPXR was sequenced in a cohort of 121 Caucasian ICP patients and exon 2 was sequenced in an additional 226 cases. Reporter assays were used to evaluate the function of...

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Identifiers

PMID: 18800312
DOI: 10.1080/00498250802426114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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