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Article

Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.

Molecular and cellular biology - 1 Apr 1997

Noguchi E, Hayashi N, Nakashima N, Nishimoto T

Abstract excerpt

The Ran-GTPase cycle is important for nucleus-cytosol exchange of macromolecules and other nuclear processes. We employed the two-hybrid method to identify proteins interacting with Ran and the Ran GTP/GDP exchange factor. Using PRP20, encoding the Ran GTP/GDP exchange factor, we identified YRB1, previously identified as a protein able to interact with human Ran GTP/GDP exchange factor RCC1 in the two-hybrid...

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Identifiers

PMID: 9121474
DOI: 10.1128/MCB.17.4.2235
PMCID: PMC232073

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.PMID 9121474Read ↗

Mutants in a yeast Ran binding protein are defective in nuclear transport.Semantic proximity Read ↗

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus.Semantic proximity Read ↗

Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects.Semantic proximity Read ↗

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.Semantic proximity Read ↗

RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.Semantic proximity Read ↗

A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system.Semantic proximity Read ↗

Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nuclear PRP20 protein is required for mRNA export.Semantic proximity Read ↗

Overexpression of Bud5p can suppress mutations in the Gsp1p guanine nucleotide exchange factor Prp20p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Isolation of a novel rmn1 gene genetically linked to spnab2 with respect to mRNA export in fission yeast.Semantic proximity Read ↗

Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase.Semantic proximity Read ↗

Requirements for the nuclear export of the small ribosomal subunit.Semantic proximity Read ↗

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