Article
Analysis of yeast prp20 mutations and functional complementation by the human homologue RCC1, a protein involved in the control of chromosome condensation.
Molecular & general genetics : MGG - 1 Jul 1991
Fleischmann M, Clark M W, Forrester W, Wickens M, Nishimoto T, Aebi M
Abstract excerpt
Mutations in the PRP20 gene of yeast show a pleiotropic phenotype, in which both mRNA metabolism and nuclear structure are affected. srm1 mutants, defective in the same gene, influence the signal transduction pathway for the pheromone response. The yeast PRP20/SRM1 protein is highly homologous to the RCC1 protein of man, hamster and frog. In mammalian cells, this protein is a negative regulator for initiation of...
Topics
- Alleles
- Blotting, Western
- Cell Cycle Proteins
- Chromosomes, Fungal
- Chromosomes, Human
- DNA-Binding Proteins
- Electrophoresis, Polyacrylamide Gel
- Fluorescent Antibody Technique
- Genes, Fungal
- Genetic Complementation Test