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Article

Site-directed mutagenesis of the yeast PRP20/SRM1 gene reveals distinct activity domains in the protein product.

Molecular & general genetics : MGG - 17 Oct 1994

Lee A, Clark K L, Fleischmann M, Aebi M, Clark M W

Abstract excerpt

Prp20/Srm1, a homolog of the mammalian protein RCC1 in Saccharomyces cerevisiae, binds to double-stranded DNA (dsDNA) through a multicomponent complex in vitro. This dsDNA-binding capability of the Prp20 complex has been shown to be cell-cycle dependent; affinity for dsDNA is lost during DNA replication. By analyzing a number of temperature sensitive (ts) prp20 alleles produced in vivo and in vitro, as well as...

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Source

Identifiers

PMID: 7845357
DOI: 10.1007/BF00279748

Genes

RCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Site-directed mutagenesis of the yeast PRP20/SRM1 gene reveals distinct activity domains in the protein product.PMID 7845357Read ↗

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