A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation.

doi:10.1007/BF00259453

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Article

A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation.

Molecular & general genetics : MGG - 1 Oct 1990

Aebi M, Clark M W, Vijayraghavan U, Abelson J

Abstract excerpt

We report on the characterization of the yeast prp20-1 mutant. In this temperature-sensitive mutant, multiple steps of mRNA metabolism are affected. The prp20-1 mutant strain showed alterations in mRNA steady-state levels, defective mRNA splicing and changes in transcription initiation or termination when shifted from the permissive to the non-permissive temperature. In addition, a change in the structure of the...

Topics

Amino Acid Sequence
Cell Cycle Proteins
Cell Nucleus
Chromosomes, Fungal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Guanine Nucleotide Exchange Factors
Humans
Microscopy, Electron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

RNA Splicing

RNA, Fungal

RNA, Messenger

Restriction Mapping

Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 2277633
DOI: 10.1007/BF00259453

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2277633-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation.PMID 2277633Read ↗

Nuclear PRP20 protein is required for mRNA export.Semantic proximity Read ↗

Analysis of yeast prp20 mutations and functional complementation by the human homologue RCC1, a protein involved in the control of chromosome condensation.Semantic proximity Read ↗

Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.Semantic proximity Read ↗

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