RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.

doi:10.1007/BF00290397

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Article

RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.

Molecular & general genetics : MGG - 25 Jun 1995

Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T

Abstract excerpt

A human protein that is 92% identical and 97% homologous at the amino acid level to RanBP1 from mouse was identified by the two-hybrid method, using two types of target cDNAs fused to sequences encoding the GAL4 DNA-binding domain. The target cDNAs encoded the human Ran/TC4 and human RCC1 proteins, respectively. An in vitro binding experiment showed that RanBP1 binds to RCC1 with the aid of Ran. Partially...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Cycle Proteins
Cell Line
Cricetinae
DNA, Complementary
DNA-Binding Proteins
GTP-Binding Proteins
Guanine Nucleotide Exchange Factors
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Nuclear Proteins

Phenotype

Protein Binding

RNA-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 7616957
DOI: 10.1007/BF00290397

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7616957-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.PMID 7616957Read ↗

Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.Semantic proximity Read ↗

Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae.Semantic proximity Read ↗

The yeast SRM1 protein and human RCC1 protein share analogous functions.Semantic proximity Read ↗

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutants in a yeast Ran binding protein are defective in nuclear transport.Semantic proximity Read ↗

Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects.Semantic proximity Read ↗

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.Semantic proximity Read ↗

Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein.Semantic proximity Read ↗

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Semantic proximity Read ↗

Analysis of yeast prp20 mutations and functional complementation by the human homologue RCC1, a protein involved in the control of chromosome condensation.Semantic proximity Read ↗

Site-directed mutagenesis of the yeast PRP20/SRM1 gene reveals distinct activity domains in the protein product.Semantic proximity Read ↗

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