Article
Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.
The Journal of biological chemistry - 25 Jul 1992
Osterop A P, Medema R H, Bos J L, vd Zon G C, Moller D E, Flier J S, Möller W, Maassen J A
Abstract excerpt
We showed previously that upon insulin stimulation of an insulin receptor overexpressing cell line, most of the p21ras was rapidly converted into the GTP bound state (Burgering, B. M. T., Medema, R. H., Maassen, J. A., Van de Wetering, M. L., Van der Eb, A. J., McCormick, F., and Bos, J. L. (1991) EMBO J. 10, 1103-1109). To determine whether this process also occurs in cells expressing physiologically relevant...
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