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Article

The aging hippocampus: interactions between exercise, depression, and BDNF.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Feb 2012

Erickson Kirk I, Miller Destiny L, Roecklein Kathryn A

Abstract excerpt

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude...

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Identifiers

PMID: 21531985
DOI: 10.1177/1073858410397054
PMCID: PMC3575139

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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