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Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Mar 2012

Hajek Tomas, Kopecek Miloslav, Höschl Cyril

Abstract excerpt

OBJECTIVES: Converging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure. Yet the majority of studies have shown no effect of this polymorphism on hippocampal volumes, perhaps due to small effect size. METHODS: We performed a meta-analysis of studies investigating the association between Val66Met BDNF polymorphism and hippocampal volumes in...

Topics

Brain-Derived Neurotrophic Factor
Endophenotypes
Genotype
Heterozygote
Hippocampus
Humans
Magnetic Resonance Imaging
Mutation, Missense
Organ Size
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 21722019
DOI: 10.3109/15622975.2011.580005
PMCID: PMC4831902

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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