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Article

Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.

Synapse (New York, N.Y.) - 1 Jul 2005

Giménez-Llort Lydia, Masino Susan A, Diao Lihong, Fernández-Teruel Alberto, Tobeña Adolf, Halldner Linda, Fredholm Bertil B

Abstract excerpt

Using mice with a targeted disruption of the adenosine A1 receptor (A1R), we examined the role of A1Rs in hippocampal long-term potentiation (LTP), long-term depression (LTD), and memory formation. Recordings from the Shaffer collateral-CA1 pathway of hippocampal slices from adult mice showed no differences between theta burst and tetanic stimulation-induced LTP in adenosine A1 receptor knockout (A1R-/-),...

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Identifiers

PMID: 15858837
DOI: 10.1002/syn.20146
PMCID: PMC2213905

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Source receipt: pubmed, retrieved 7 Sept 2026.

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