Article
Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.
Synapse (New York, N.Y.) - 1 Jul 2005
Giménez-Llort Lydia, Masino Susan A, Diao Lihong, Fernández-Teruel Alberto, Tobeña Adolf, Halldner Linda, Fredholm Bertil B
Abstract excerpt
Using mice with a targeted disruption of the adenosine A1 receptor (A1R), we examined the role of A1Rs in hippocampal long-term potentiation (LTP), long-term depression (LTD), and memory formation. Recordings from the Shaffer collateral-CA1 pathway of hippocampal slices from adult mice showed no differences between theta burst and tetanic stimulation-induced LTP in adenosine A1 receptor knockout (A1R-/-),...
Topics
- Animals
- Cues
- Electrophysiology
- Excitatory Postsynaptic Potentials
- Genotype
- Habituation, Psychophysiologic
- Hippocampus
- Maze Learning
- Memory, Short-Term
- Mice
- Mice, Inbred C57BL
- Neuronal Plasticity
- Receptor, Adenosine A1