Article
Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity.
Brain structure & function - 1 Jan 2016
Olivito Laura, Saccone Paola, Perri Valentina, Bachman Julia L, Fragapane Paola, Mele Andrea, Huganir Richard L, De Leonibus Elvira
Abstract excerpt
Memory capacity (MC) refers to the number of elements one can maintain for a short retention interval. The molecular mechanisms underlying MC are unexplored. We have recently reported that mice as well as humans have a limited MC, which is reduced by hippocampal lesions. Here, we addressed the molecular mechanisms supporting MC. GluA1 AMPA-receptors (AMPA-R) mediate the majority of fast excitatory synaptic...
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