Article
An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression.
Neuron - 1 Dec 1998
Chiang M Y, Misner D, Kempermann G, Schikorski T, Giguère V, Sucov H M, Gage F H, Stevens C F, Evans R M
Abstract excerpt
Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. We report here that RARbeta deficiency in mice virtually eliminates hippocampal CA1 LTP and LTD. It also results in substantial performance deficits in spatial learning and memory tasks. Surprisingly, RXRgamma null mice exhibit a distinct...
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