Article
Genetic and pharmacological demonstration of differential recruitment of cAMP-dependent protein kinases by synaptic activity.
Journal of neurophysiology - 1 Dec 2000
Woo N H, Duffy S N, Abel T, Nguyen P V
Abstract excerpt
cAMP-dependent protein kinase (PKA) is believed to play a critical role in the expression of long-lasting forms of hippocampal long-term potentiation (LTP). Can distinct patterns of synaptic activity induce forms of LTP that require different isoforms of PKA? To address this question, we used transgenic mice that have genetically reduced hippocampal PKA activity, and a specific pharmacological inhibitor of PKA,...
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