Article
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.
Cell - 7 Oct 1994
Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva A J
Abstract excerpt
The cAMP-responsive element-binding protein (CREB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studies with fear conditioning and with the water maze show that mice with a targeted disruption of the alpha and delta isoforms of CREB are profoundly deficient in long-term memory. In contrast, short-term memory, lasting...
Topics
- Animals
- Association Learning
- Conditioning, Psychological
- Cyclic AMP Response Element-Binding Protein
- Electrophysiology
- Female
- Hippocampus
- Long-Term Potentiation
- Male
- Memory
- Mice